Category: Research

Neural Engineering applies engineering principles to solve questions in brain research and to the development of treatments for neurological disorders.

Cancer Therapy

In Neural Imaging, Dr. Parra is collaborating with Memorial-Sloan Kettering Cancer Center to develop tools for the analysis of Magnetic Resonance Spectroscopic Imaging (MRSI). The goal is to identify markers of metabolic function that are indicative of brain tumors. Dr Bikson is concurrently developing technology to facilitate drug delivery to

Safety Validation and Clinical Testing

Safety Validation Evidently, safety is paramount when deploying an clinical device.  In addition to exhaustively considering risks associated with the devices we develop, our group has also provided expert advice of medical device and electrical safety to a range of companies and institutes including the counties leading medical device corporations.  Pre-clinical

Reading The Brain

Our work in Neural Signal Processing focuses on developing signal analysis tools for imaging the central nervous system. We emphasize multivariate signal analysis and probabilistic modeling, drawing heavily on advanced machine learning techniques. Projects on functional imaging are based on Electro-Encephalography (EEG). Experiments in Parra’s high-density EEG recording lab study

Quantitative Neurophysiology with Applied Electric Fields

  Precisely how electricity changes nervous system function can be fully characterized, understood, and then leveraged to design electrical therapies. To understand the biophysics of electric-nervous tissue interactions, we have developed a research program structures along three “tiers” of characterization.   The tiers are evidently not independent (the nervous system is

Endogenous Field Effects and Timing

For example, our group has identified “spike-timing” as a mechanism for field effect modulation of neuronal function and developed/validated basic quantitative models of field modulation of spike-timing.  Despite extensive theoretical studies of neuronal network oscillations and coherent activity, scarce studies analyze this potentially unique and pivotal role of field effects

The role of endogenous field effects in nervous system function

Field effects (also called ‘ephaptic interaction’) refer to neuronal interactions mediated by electrical current flowing through the extracellular space. Simply put: When current is generated across a cell membrane, for example as during an action potential, a current will also be generated in the extracellular space around that cell; this

Non-synaptic mechanisms and Epilepsy

Non-synaptic mechanisms exert a powerful influence on seizure threshold. Dr. Jefferys among others established that non-synaptic mechanisms are actually sufficient in themselves to induce seizures and illustrated by epileptiform activity induced in hippocampal slices by reducing extracellular Ca2+ concentration. We showed that non-synaptic epileptiform activity can also be readily induced